Nixodine® is a lab-made (synthetic) alkaloid created for adult vapers. It isn’t nicotine, and it isn’t made from tobacco or nicotine. It’s designed to give an experience similar to nicotine, and its maker says it works on the same receptors in the body that nicotine does. Air Factory makes Nixodine e-liquid in five flavors, in 100ml and 30ml bottles.
What is Nixodine made of?
Nixodine is made by Bonguard Naturals, which describes it as a “synthetically derived alkaloid” that is “not derived from tobacco or nicotine.” It is covered by U.S. patents, starting with patent 11,964,958, titled “Vaporizable alkaloid compositions and methods of use thereof.” The maker says it is almost tasteless and odorless, so it can be blended into regular e-liquid without changing the flavor.
The maker hasn’t published a full formula yet and says a scientific white paper is on the way. Independent researchers writing about Nixodine-branded products in 2024 described them as containing nicotinamide, a form of vitamin B3, and a lab-made compound called 6-methylnicotine.
Air Factory Nixodine e-liquid lists its ingredients on every bottle: vegetable glycerin, propylene glycol, artificial and natural flavorings, and Nixodine. Unflavored has no flavorings, just PG, VG and Nixodine.
How is Nixodine different from nicotine?
- It isn’t nicotine. Nixodine is a different compound, made in a lab rather than from tobacco.
- It targets the same receptors. The maker says Nixodine acts on nicotinic receptors, the same ones nicotine acts on, to give a similar feeling.
- It’s labeled differently. Nicotine e-liquid is sold in milligrams. Air Factory Nixodine shows its strength as a number: 3 or 6 on the 100ml bottle, and 18, 35 or 50 on the 30ml bottle.
- It’s a separate product line. If you want nicotine e-liquid, Air Factory’s 60ml E-Liquid and 30ml Salts are separate lines. Air Factory Nixodine is not for use with tobacco or nicotine products.
Rules for nicotine alternatives differ from state to state, so whether retailers can ship Nixodine to you depends on where you live.
Is Nixodine safe? Is it addictive?
No vape product is safe or free of risk, and Nixodine is no exception. Its maker says Nixodine “may be addictive, may be acutely toxic and, like nicotine, should be used with caution.” The U.S. Food and Drug Administration has not evaluated the maker’s statements about it.
- Who it’s for: its maker says Nixodine is intended for adults 21 and over who already use nicotine or vape products.
- Who should not use it: minors, non-smokers and people who don’t already vape, and anyone who is pregnant or nursing. People with medical conditions such as heart disease, high blood pressure, asthma or diabetes, or who take medication, should talk to a doctor first.
- Possible side effects listed by the maker: nausea, coughing, headache, mouth or throat irritation, dizziness and heart palpitations. Stop using it and get medical help if these happen.
- It isn’t a quit-smoking product. For help quitting, visit smokefree.gov.
- Keep it away from children and pets. Swallowing e-liquid can be poisonous; call poison control if it happens.
California Proposition 65 warning: Nixodine vaping products can expose you to chemicals including formaldehyde, which is known to the State of California to cause cancer. For more information go to www.P65Warnings.ca.gov.
Air Factory Nixodine flavors, sizes and strengths
Every Air Factory Nixodine flavor comes in two bottle sizes. The 100ml bottle comes in strength 3 or 6. The 30ml bottle comes in strength 18, 35 or 50.
| Flavor | What it tastes like | 100ml | 30ml |
|---|---|---|---|
| Blue Razz | A blast of blue raspberry. Mildly sweet, mellow, with light creamy undertones. | Strength 3 or 6 | Strength 18, 35 or 50 |
| Menthol | A traditional menthol flavor with a fresh finish. | Strength 3 or 6 | Strength 18, 35 or 50 |
| Mint | The crisp, refreshing flavor of mint with a fresh finish. | Strength 3 or 6 | Strength 18, 35 or 50 |
| Tobacco | Familiar, flavorful tobacco with complex notes. | Strength 3 or 6 | Strength 18, 35 or 50 |
| Unflavored | No flavoring: just PG, VG and Nixodine. | Strength 3 or 6 | Strength 18, 35 or 50 |
See the whole line on the Air Factory Nixodine page. Don’t mix Nixodine e-liquid with other e-liquids.
Where to buy Air Factory Nixodine
Air Factory doesn’t sell online directly. Pick a flavor above, then choose one of our authorized retailers on that product page. Join our email list to get partner promo codes when they drop.
Nixodine FAQ
Is Nixodine nicotine?
No. Nixodine is a synthetic alkaloid, and its maker says it is not derived from tobacco or nicotine.
Does Nixodine give you a buzz?
It’s designed to give a feeling similar to nicotine. Its maker says it acts on the same receptors nicotine does.
Is Nixodine addictive?
Its maker says it may be addictive and should be used with caution, like nicotine.
What are the side effects of Nixodine?
The maker lists nausea, coughing, headache, mouth or throat irritation, dizziness and heart palpitations among possible side effects. Stop using it and get medical help if they happen.
What strengths does Air Factory Nixodine come in?
The 100ml bottle comes in strength 3 or 6, and the 30ml bottle in strength 18, 35 or 50. Nixodine strength is shown as a number, not in milligrams.
Who can buy Nixodine?
Air Factory Nixodine is intended for adults and is not for sale to minors. Its maker says Nixodine is for adults 21 and over.
Sources: Nixodine® by Bonguard Naturals; Jabba SV, Jordt SE, “Marketing of nicotinamide as nicotine replacement in electronic cigarettes and smokeless tobacco,” Tobacco Prevention & Cessation, 2024. Statements about Nixodine have not been evaluated by the FDA. This product is not intended to diagnose, treat or cure any disease.